diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 5da3c2d78a9017e2f1862a6c8f6cce2630684e9c..01bd4f81d5758b179a80454f3721d04dda692a80 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -8,6 +8,9 @@ before_script:
   - python -m pip install --upgrade pip
   - python --version
   - pip install pytest pytest-cov sphinx furo numpydoc pytest-xvfb pytest-qt setuptools_scm sphinx-qt-documentation pytest-xdist pytest-mpl
+  - pip install $QT_API
+  - export PYTEST_QT_API=$QT_API
+  - export QT_API=$QT_API
   # - export CXXFLAGS='--coverage'
   - pip install -ve .
   # Move file, but should be handled by installation
@@ -30,19 +33,59 @@ before_script:
   coverage: /(?i)total.*? (100(?:\.0+)?\%|[1-9]?\d(?:\.\d+)?\%)$/
 
 
-run-test-3.8:
+run-test-3.8-pyside2:
+  variables:
+    QT_API: pyside2
   image: python:3.8
   extends: ".run-test"
 
-run-test-3.9:
+run-test-3.8-pyqt5:
+  variables:
+    QT_API: pyqt5
+  image: python:3.8
+  extends: ".run-test"
+
+run-test-3.9-pyside2:
+  variables:
+    QT_API: pyside2
+  image: python:3.9
+  extends: ".run-test"
+
+run-test-3.9-pyqt5:
+  variables:
+    QT_API: pyqt5
   image: python:3.9
   extends: ".run-test"
 
-run-test-3.10:
+run-test-3.10-pyside2:
+  variables:
+    QT_API: pyside2
+  image: python:3.10
+  extends: ".run-test"
+
+run-test-3.10-pyqt5:
+  variables:
+    QT_API: pyqt5
+  image: python:3.10
+  extends: ".run-test"
+
+run-test-3.10-pyside6:
+  variables:
+    QT_API: pyside6
+  image: python:3.10
+  extends: ".run-test"
+  allow_failure: true
+
+run-test-3.10-pyqt6:
+  variables:
+    QT_API: pyqt6
   image: python:3.10
   extends: ".run-test"
+  allow_failure: true
 
 run-doc-test:
+  variables:
+    QT_API: pyside2
   image: python:3.10
   stage: test
   script:
@@ -53,6 +96,8 @@ run-doc-test:
 #  extends: ".run-test"
 
 pages:
+  variables:
+    QT_API: pyqt5
   stage: deploy
   image: python:3.10
   script:
diff --git a/pyproject.toml b/pyproject.toml
index 32b7026b95ee88bf1b6bc6c47a2fe68b2b4e2773..180be81b1c97329fdf0c89ea90477a0083a361b4 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -10,7 +10,7 @@ requires-python = ">=3.8"
 dependencies = [
     "numpy",
     "pybind11>=2.3.0",
-    "pyside2",
+    # "pyside2",
     "qtpy",
     "graphviz>=0.19",
     "matplotlib",